Receptor Grade IGF-1 LR3 (100mcg)

High-Purity Synthetic Analog for Enhanced Anabolic Research

IGF-1 LR3 (Long Arg3 Insulin-like Growth Factor-1) is a synthetic variant of the naturally occurring 70-amino acid protein IGF-1. It is specifically engineered with a 13-amino acid extension at the N-terminal and a substitution of glutamic acid with arginine at the third position. The "Receptor Grade" designation refers to its superior purity level compared to Media Grade, making it ideal for sensitive cell culture and laboratory studies.

Core Benefits & Research Focus

The structural modifications in IGF-1 LR3 significantly alter its biological behavior, increasing its potency in research models:

• Increased Anabolic Potential: Modified to have a much lower affinity for IGF-1 binding proteins (IGF-BPs), allowing the peptide to circulate more freely and interact more effectively with receptors. In murine models, it was observed to be 1.5 to 2 times as anabolic as standard IGF-1.

• Muscle Preservation: Research suggests it can reduce markers of muscle protein breakdown (such as Nτ-methylhistidine) up to three times more effectively than endogenous IGF-1.

• Insulin Sensitivity & Glucose Metabolism: Investigated for its ability to stimulate glucose uptake via the PI3K and AMPK pathways, potentially improving insulin sensitivity.

• Myostatin Inhibition: Studied for its potential to decrease the action of myostatin—a protein that prevents cellular differentiation—thereby supporting the development of lean muscle mass.

• Cell Lifespan: Preliminary studies indicate that routine exposure may mitigate physiological decline markers like muscle tears and neurological deficiencies, potentially supporting the lifespan of functional cells.

Technical Specifications

Research Findings: Pharmacokinetics

• Rapid Clearance & Distribution: Unlike standard IGF-1, which binds heavily to proteins, IGF-1 LR3 clears from the serum more quickly and distributes more evenly into tissues such as the kidneys, ovaries, and adrenal glands.

• Bioavailability: Its diminished propensity to form complexes with IGFBPs significantly enhances its bioavailable concentration in experimental models.

Safety & Storage

• Usage Disclaimer: This product is sold for research and laboratory purposes only and is not for human consumption.

• Storage: Store the lyophilized powder at -20°C for long-term stability. Once reconstituted, avoid repeated freeze-thaw cycles and use within a short timeframe while keeping refrigerated.