Ipamorelin 10mg (Growth Hormone Secretagogue)

Ipamorelin is a synthetic pentapeptide and a potent, highly selective growth hormone secretagogue (GHS). It belongs to the class of GH-releasing peptides (GHRPs) that mimic the action of ghrelin by binding to the growth hormone secretagogue receptor (GHSR) in the brain. Unlike earlier generations of peptides in this category, Ipamorelin is unique because it is significantly more selective. It stimulates the pituitary gland to release growth hormone without significantly impacting the production of cortisol, prolactin, or ACTH (adrenocorticotropic hormone).

This 10mg formulation is designed for researchers and individuals looking to support the body's natural pulsatile release of growth hormone. By encouraging the body to produce its own growth hormone rather than introducing synthetic hormones, Ipamorelin offers a more natural approach to physical recovery, body composition improvement, and anti-aging metabolic support.

Primary Benefits to the Body

The selective activation of growth hormone receptors by Ipamorelin leads to several systemic benefits related to repair, metabolism, and vitality:

Enhanced Muscle Tissue Growth: By increasing the circulating levels of growth hormone and IGF-1 (Insulin-like Growth Factor 1), Ipamorelin supports the development of lean muscle mass and assists in muscle cell hyperplasia. Accelerated Fat Metabolism: Growth hormone is a powerful lipolytic agent. Higher levels of GH signal the body to mobilize stored fat for energy, particularly in the abdominal region. Improved Bone Mineral Density: GH plays a critical role in bone remodeling. Consistent use of Ipamorelin may help increase bone strength by stimulating the cells responsible for bone formation. Enhanced Recovery and Repair: The peptide supports the repair of connective tissues, skin, and organs, leading to faster recovery from strenuous exercise or injury. Improved Sleep Quality: Growth hormone is naturally released during deep sleep. Supplementing with a secretagogue like Ipamorelin has been shown to improve the depth and quality of the circadian rhythm. Cellular Rejuvenation: Often associated with anti-aging protocols, increased GH levels contribute to better skin elasticity, hair quality, and overall cellular health.

Normal Dosage and Administration

Ipamorelin is typically administered via subcutaneous injection. To mimic the body's natural rhythms, it is often administered in the evening or split into multiple doses.

Standard Dosage Guidelines:

General Anti-Aging/Recovery: 200 mcg to 300 mcg once daily, usually before bed. Performance/Muscle Support: 200 mcg to 300 mcg, administered two to three times per day. Timing: For maximum effectiveness, it should be taken on an empty stomach (at least 2 hours after a meal and 30 minutes before eating again) to prevent insulin from blunting the GH pulse.

Administration Instructions:

1. Reconstitution: If in lyophilized (powder) form, add 2ml to 3ml of Bacteriostatic Water to the vial. Allow it to dissolve naturally without shaking.

2. Injection: Use a small-gauge needle to inject into the fatty tissue of the abdomen.

3. Cycle Duration: Common protocols last between 8 to 12 weeks, followed by a 4-week break to maintain receptor sensitivity.

How to Store

Ipamorelin is a delicate peptide and must be handled with care to maintain its structural integrity.

Pre-Reconstitution (Powder): Store in a cool, dark place. For long-term storage (over 3 months), it should be kept in the freezer at -20°C. Post-Reconstitution (Liquid): Once mixed, the vial must be kept in the refrigerator at 2°C to 8°C (36°F to 46°F). Stability: Do not freeze the peptide once it has been reconstituted. If the liquid freezes, the peptide bonds may break, rendering it ineffective. Vial Handling: Avoid excessive agitation or dropping the vial, as mechanical stress can damage the peptide chains.

Important Educational Information

Understanding why Ipamorelin is preferred over other GHRPs is essential for an informed protocol.

The "Safety" Profile Ipamorelin is often called the "cleanest" GHRP because it does not cause the "hunger spikes" associated with GHRP-6 or the cortisol/prolactin increases associated with GHRP-2. This makes it ideal for long-term use without the risk of unwanted hormonal side effects.

Synergy with GHRH Ipamorelin is frequently combined with a GHRH (Growth Hormone Releasing Hormone) such as CJC-1294. While Ipamorelin triggers the "pulse" of GH from the pituitary, a GHRH increases the strength of that pulse. Using them together can result in a significantly higher release of GH than using either alone.

Potential Side Effects While rare and usually mild, some users may experience:

• A slight "head rush" immediately after injection

• Temporary redness or itching at the injection site

• Mild water retention in the extremities during the first week

• Increased vividness of dreams

Hormonal Comparison Table

Feature: Ipamorelin Cortisol/Prolactin Increase: None to Minimal Hunger Stimulation: Very Low GH Pulse Type: Selective & Natural Best For: Long-term anti-aging and lean muscle

Feature: GHRP-2 Cortisol/Prolactin Increase: Moderate Hunger Stimulation: Moderate GH Pulse Type: Strong Best For: Rapid recovery and GH deficiency

Feature: GHRP-6 Cortisol/Prolactin Increase: Moderate Hunger Stimulation: Very High GH Pulse Type: Strong Best For: Mass gain and appetite stimulation