HGH Frag 176-191

A Specialized Fragment for Advanced Adipose Tissue Research

HGH Frag 176-191 is a stabilized, synthetic analogue of the C-terminal region of Human Growth Hormone. This specific sequence—comprising amino acids 176 through 191—is recognized by researchers as the "lipolytic fragment," the precise portion of the growth hormone molecule responsible for stimulating fat metabolism.

Unlike the full-length growth hormone molecule, HGH Frag 176-191 is uniquely selective. It mimics the natural growth hormone's ability to regulate fat metabolism without the unwanted systemic effects, such as interference with insulin sensitivity or the promotion of vertical growth. This makes it a primary subject of study for targeted weight management and metabolic optimization.

Core Benefits to the Body

In laboratory and clinical research, HGH Frag 176-191 demonstrates several specific physiological advantages:

• Potent Lipolysis: It triggers the breakdown of fat by stimulating the beta-3 adrenergic receptors, which primarily reside in adipose tissue.

• Inhibition of Lipogenesis: Beyond burning existing fat, it has shown the ability to inhibit the formation of new fatty acids and lipids within the body.

• Stable Blood Glucose: Because it lacks the "growth" portion of the GH molecule, it does not compete for HGH receptors that affect insulin, thereby avoiding the risk of hyperglycemia.

• Enhanced Energy Levels: By facilitating the mobilization of fat stores into usable energy, it can support metabolic rate and physical endurance.

• Targeted Stubborn Fat: Research focuses heavily on its effectiveness in reducing visceral and abdominal adipose tissue.

Technical Specifications

The following data represents the standard pharmaceutical-grade profile of the HGH Frag 176-191 peptide:

Preparation and Dosage Guidance

To maintain the structural integrity of the peptide, proper reconstitution and administration protocols are essential:

• Reconstitution: This lyophilized powder must be mixed with Sterile Water or Bacteriostatic Water. The diluent should be injected slowly down the side of the vial to avoid damaging the peptide through foaming.

• Standard Research Dosage: Laboratory protocols often utilize dosages ranging from 250 mcg to 500 mcg per day.

• Timing for Efficacy: For maximum lipolytic effect, research indicates it is best administered in a fasted state (usually morning or before bed), as the presence of insulin from food intake can blunt its fat-burning properties.

Storage and Handling Instructions

Peptides are delicate compounds that require specific environmental conditions to remain viable:

• Unopened Vials (Lyophilized): Store in a refrigerator at 2°C to 8°C (36°F–46°F) for short-term use. For long-term storage exceeding one month, the powder should be kept in a freezer at -20°C.

• Reconstituted Solution: Once liquid, the peptide is highly sensitive. It must be kept refrigerated and used within 7 to 10 days.

• Strict Precaution: Do not shake the vial at any time; gentle swirling is sufficient to dissolve the powder. Protect from direct UV light and extreme heat.

Educational Information for Researchers

HGH Frag 176-191 is an invaluable tool for studying "Metabolic Flexibility"—the body's ability to switch between burning carbohydrates and fats for fuel. Unlike the 191-amino acid HGH, this fragment does not promote the secretion of IGF-1, meaning it does not cause bone or organ growth. This selectivity allows researchers to isolate and study the lipolytic pathway without the confounding variables of systemic growth stimulation.