Cagrilintide 10mg

A Long-Acting Amylin Analog for Advanced Appetite Regulation

Cagrilintide is a revolutionary, long-acting acylated analog of the natural hormone amylin. While traditional amylin breaks down rapidly in the body, Cagrilintide has been engineered for extreme stability, featuring a specialized fatty acid attachment that allows it to remain active for an extended period. As a nonselective agonist of amylin receptors (AMYR) and calcitonin G protein-coupled receptors (CTR), it targets the biological drivers of hunger and satiety at a foundational level.

This peptide is primarily recognized for its potent ability to induce significant weight loss and reduce caloric intake by mimicking the body's natural "fullness" signals. Its unique mechanism of action makes it a focal point of modern metabolic research, particularly when studied in conjunction with GLP-1 receptor agonists like Semaglutide.

Core Benefits to the Body

Cagrilintide offers a multi-layered approach to metabolic health by influencing several physiological pathways simultaneously:

• Powerful Appetite Suppression: It activates satiety centers in the brain's hypothalamus and brainstem, naturally lowering food cravings and reducing portion sizes without the need for stimulants.

• Delayed Gastric Emptying: By slowing the rate at which food leaves the stomach, it extends the feeling of fullness and satisfaction after meals.

• Enhanced Glycemic Control: It helps regulate post-meal blood sugar spikes and suppresses glucagon secretion, supporting overall insulin sensitivity and energy balance.

• Cardiometabolic Support: Indirectly, the significant weight reduction associated with Cagrilintide can lead to improved blood pressure, lower cholesterol, and reduced inflammatory markers.

• Synergistic Potential: When used alongside other metabolic therapies, it provides a "dual-pathway" approach, often leading to more dramatic results than single-agent protocols.

Technical Specifications & Dosage

In research settings, Cagrilintide is typically administered via subcutaneous injection once weekly due to its long half-life.

Storage and Handling Instructions

Proper storage is critical to maintaining the structural integrity and potency of this acylated peptide.

• Lyophilized Powder (Unopened): For long-term preservation, store at -20°C (up to 1 year) or -80°C (up to 2 years). For short-term use, a standard refrigerator (4°C) is acceptable for up to 3 months.

• Reconstituted Solution: Once mixed with a solvent (such as Bacteriostatic Water), the solution is significantly less stable. It should be kept refrigerated at 4°C and used within 1–2 weeks. For slightly longer storage of up to 1 month, it must be kept at -20°C.

• Environmental Factors: Always keep the vial sealed and protected from direct sunlight and moisture. Avoid repeated freeze-thaw cycles, as this can cause the peptide to degrade.

Educational Information for Researchers

Cagrilintide represents a shift in weight management science, moving from simple caloric restriction to hormonal optimization. Researchers should note that gastrointestinal side effects—such as mild nausea or constipation—are common during the initial "titration" phase and typically resolve as the body adapts to the peptide. Because of its high potency, it is standard practice to start at a very low dose and increase gradually over several weeks to ensure tolerability.